ETHNOBOTANICAL, PHYTOCHEMICAL, PHARMACOLOGICAL AND TOXICOLOGICAL ASPECTS OF AFSANTEEN (ARTEMISIA ABSINTHIUM L.) AND ITS THERAPEUTIC APPLICATION IN UNANI MEDICINE: AN UPDATED REVIEW
Abstract : The plant Artemisia absinthium L., also referred to as Afsanteen in Unani medicine, is part of Asteraceae family and is widely used to treat a range of serious illnesses. The bioactive compounds present in A. absinthium are frequently utilized to manage several medical conditions, including cancer, malaria, gastrointestinal, liver, and kidney issues.
Cite : Maseehullah, M. (2023). Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects of Afsanteen (Artemisia Absinthium L.) and its Therapeutic Application in Unani Medicine: An Updated Review (1st ed., pp. 150-161). Noble Science Press. https://doi.org/10.52458/9789388996983.nsp2023.eb.ch-20
References :
Jha S.et.al 2023 Vaiphei "KK," Alexander A. Plant-based therapeutics: current status and future perspectives. Phytopharmaceuticals and Herbal Drugs. 1:3-11.
Lam, C. S., Zhou, K., Loong, H. H. F., Chung, V. C. H., Ngan, C. K., & Cheung, Y. T. (2023). The Use of Traditional, Complementary, and Integrative Medicine in Cancer: Data-Mining Study of 1 Million Web-Based Posts From Health Forums and Social Media Platforms. Journal of Medical Internet Research, 25, e45408.
Batiha, G. E. S., Olatunde, A., El-Mleeh, A., Hetta, H. F., Al-Rejaie, S., Alghamdi, S., ... & Rivero-Perez, N. (2020). Bioactive compounds, pharmacological actions, and pharmacokinetics of wormwood (Artemisia absinthium). Antibiotics, 9(6), 353.
Sina I. Al Qanun fit Tibb, English translation of the critical text. Book I. New Delhi: Jamia Hamdard; 1993: 119-120,127.
Szopa, A., Pajor, J., Klin, P., Rzepiela, A., Elansary, H. O., Al-Mana, F. A., ... & Ekiert, H. (2020). Artemisia absinthium L.—Importance in the history of medicine, the latest advances in phytochemistry and therapeutical, cosmetological and culinary uses. Plants, 9(9), 1063.
Osbaldeston TA, Wood RPA. Dioscorides (English Translation). Ibidis Press, Parkhurst Johannesburg South Africa, 2000:392.
Khan, F. A., Khan, N. M., Ahmad, S., Nasruddin, Aziz, R., Ullah, I., ... & Aljuaid, A. (2022). Phytochemical profiling, antioxidant, antimicrobial and cholinesterase inhibitory effects of essential oils isolated from the leaves of Artemisia scoparia and Artemisia absinthium. Pharmaceuticals, 15(10), 1221.
Boudjelal, A., Smeriglio, A., Ginestra, G., Denaro, M., & Trombetta, D. (2020). Phytochemical profile, safety assessment and wound healing activity of Artemisia absinthium L. Plants, 9(12), 1744.
Hussain, A. (2022). A phylogenetic perspective of antiviral species of the genus Artemisia (Asteraceae-Anthemideae): A proposal of anti-SARS-CoV-2 (COVID-19) candidate taxa. Journal of Herbal Medicine, 36, 100601.
IVANESCU, B., CORCIOVA, A., VLASE, L., GHELDIU, A. M., MIRON, A., ABABEI, D. C., & Veronica, B. I. L. D. (2021). Analgesic and anti-inflammatory activity of Artemisia extracts on animal models of nociception. Balneo and PRM Research Journal, 12(1), 34-39.
Ansari, S., Siddiqui, M. A., & Maaz, M. (2018). Hepatocurative effect of Saussurea lappa CB Clarke and Artemisia absinthium, Linn in chronic hepatitis B. Journal of Young Pharmacists, 10(3), 354.
Anonymous. The Unani Pharmacopoeia of India; , 2007 Ministry of Health and Family Welfare, Dept. of AYUSH, Government of India, Part-I, Vol- 2, p. 3-4,9- 12,93-94.
KR, K. (2012). Basu BD. Indian medicinal plants. Vol. Iv. Dehradun: International Book Distributors, 1429.pp. 1398-1400.
Khare C.P. 2007-08. Indian Medicinal Plant B-1/211 Janakpuri New Delhi, pp. 63-ab,518-519, 67-68,486-487.
Pullaiah, T. (2006). Encyclopaedia of World Medicinal plants Regency Publications. University of Chicago, 1, 1377.
Nadkarni, K., & Nadkarni, A. K. (1976). Indian Materia Medica, Popular Prakashan Pvt. Ltd., Bombay, 1, 799.
Al-Baitar, I. (2000). Al Jamiul Mufradat Al Advia wal Aghzia, Vol. II (Urdu Trans: Central Council for Research in Unani Medicine). New Delhi (India): Department of AYUSH, Ministry of Health & Family Welfare, Government of India, 186-87.
Ghani H.M.N., (2004) Khazaenul Advia, Idara Kitab-ul-Shifa, Darya Ganj N Delhi pp. 245- 246, 226.
Khan, M. A. (2012). Muheet e Azam (Urdu Translation), CCRUM, New Delhi, Vol. I2, pp: 358-362,290-292,481-483.
Hakeem M.A. (2009). Bustanul Mufradat Idara Kitab-ul- shifa Koch Chelan Daryaganj New Delhi, pp.73-74.
Anonymous, Wealth of India. (2010). Vol.1: A, A dictionary of Indian Raw Materials and Industrial Products. Raw Materials, Council of Scientific and Industrial Research, New Delhi, pp; 434-435.
Juteau, F., Jerkovic, I., Masotti, V., Milos, M., Mastelic, J., Bessière, J. M., & Viano, J. (2003). Composition and antimicrobial activity of the essential oil of Artemisia absinthium from Croatia and France. Planta medica, 69(02), 158-161.
Khattak SG, Gilani SN, Ikram M (1985). Antipyretic studies on some indigenous Pakistani medicinal plants. J. Ethnopharmacol. 14: 45- 51.
Wake, G., Court, J., Pickering, A., Lewis, R., Wilkins, R., & Perry, E. (2000). CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory. Journal of ethnopharmacology, 69(2), 105-114.
Canadanovic?Brunet, J. M., Djilas, S. M., Cetkovic, G. S., & Tumbas, V. T. (2004). Free?radical scavenging activity of wormwood (Artemisia absinthium L) extracts. Journal of the Science of Food and Agriculture, 85(2), 265-272.
Tariq, K. A., Chishti, M. Z., Ahmad, F., & Shawl, A. S. (2009). Anthelmintic activity of extracts of Artemisia absinthium against ovine nematodes. Veterinary parasitology, 160(1-2), 83-88.
Kanaya, N., Adams, L., Takasaki, A., & Chen, S. (2014). Whole blueberry powder inhibits metastasis of triple negative breast cancer in a xenograft mouse model through modulation of inflammatory cytokines. Nutrition and cancer, 66(2), 242-248.
Tsuda, H., Kunitake, H., Kawasaki-Takaki, R., Nishiyama, K., Yamasaki, M., Komatsu, H., & Yukizaki, C. (2013). Antioxidant activities and anti-cancer cell proliferation properties of Natsuhaze (Vaccinium oldhamii Miq.), Shashanbo (V. bracteatum Thunb.) and blueberry cultivars. Plants, 2(1), 57-71.
Simmen, F. A., Frank, J. A., Wu, X., Xiao, R., Hennings, L. J., & Prior, R. L. (2009). Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon. BMC gastroenterology, 9, 1-9.
Gordillo, G., Fang, H., Khanna, S., Harper, J., Phillips, G., & Sen, C. K. (2009). Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm. Antioxidants & redox signaling, 11(1), 47-58.
Suh, N., Paul, S., Hao, X., Simi, B., Xiao, H., Rimando, A. M., & Reddy, B. S. (2007). Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clinical Cancer Research, 13(1), 350-355.
Schmidt, B. M., Erdman Jr, J. W., & Lila, M. A. (2006). Differential effects of blueberry proanthocyanidins on androgen sensitive and insensitive human prostate cancer cell lines. Cancer letters, 231(2), 240-246.
Matchett, M. D., MacKinnon, S. L., Sweeney, M. I., Gottschall-Pass, K. T., & Hurta, R. A. (2005). Blueberry flavonoids inhibit matrix metalloproteinase activity in DU145 human prostate cancer cells. Biochemistry and Cell Biology, 83(5), 637-643.
Vijayalakshmi, K., & SK, P. (1979). Nematicidal properties of some indigenous plant materials against second stage juneviles of Meloidogyne incognita (koffoid and white) chitwood.
Gilani, A. U. H., & Janbaz, K. H. (1995). Preventive and curative effects of Artemisia absinthium on acetaminophen and CCl4-induced hepatotoxicity. General Pharmacology: The Vascular System, 26(2), 309-315.
Caner, A., Dö?kaya, M., De?irmenci, A., Can, H., Baykan, ?., Üner, A., ... & Gürüz, Y. (2008). Comparison of the effects of Artemisia vulgaris and Artemisia absinthium growing in western Anatolia against trichinellosis (Trichinella spiralis) in rats. Experimental parasitology, 119(1), 173-179.
Ahmad, F., Khan, R. A., & Rasheed, S. (1992). Study of analgesic and anti-inflammatory activity from plant extracts of Lactuca scariola and Artemisia absinthium. Journal of Islamic Academy of Sciences, 5(2), 111-114.
Khare, C. P. (2004). Encyclopedia of indian medicinal plants: rational western therapy, ayurvedic and other traditional usage, botany. Springer.
Krebs, S., Omer, T. N., & Omer, B. (2010). Wormwood (Artemisia absinthium) suppresses tumour necrosis factor alpha and accelerates healing in patients with Crohn’s disease–a controlled clinical trial. Phytomedicine, 17(5), 305-309.
Bora, K. S., & Sharma, A. (2010). Neuroprotective effect of Artemisia absinthium L. on focal ischemia and reperfusion-induced cerebral injury. Journal of ethnopharmacology, 129(3), 403-409.
Mahmoudi, M., Ebrahimzadeh, M. A., Ansaroudi, F., Nabavi, S. F., & Nabavi, S. M. (2009). Antidepressant and antioxidant activities of Artemisia absinthium L. at flowering stage. African journal of Biotechnology, 8(24).
Shafi, N., Khan, G. A., & Ghauri, E. (2004). Antiulcereffect of Artemisia absinthium l. in rats. Biological sciences-PJSIR, 47(2), 130-134.
MMH, S., & AB, K. (1997). Effect of Afsanteen [artemisia absinthium linn.] in acute intestinal amoebiasis.