Abstract : Pharmacokinetics: The stomach and upper small intestine absorb the salicylates quickly. The stomach's acidic environment keeps a large portion of the salicylate in nonionized form, which aids absorption. However, the drug has the potential to harm the mucosal barrier. Aspirin is absorbed as is, and esterases in tissue and blood rapidly hydrolyze it to acetic acid and salicylate. Albumin binds to salicylate. Although some salicylate from food and aspirin hydrolysis is excreted unchanged, the majority is converted to water-soluble conjugates that are quickly cleared by the kidney. The rate of excretion of free salicylate is increased when the urine is alkalinized.
Keywords : muscle, vascular, dental pain.
Cite : Sharma, S. K. (2022). Anti-Inflammatory & Gout Drugs (1st ed., p. 102). Noble Science Press. https://doi.org/10.52458/9789391842529.nsp2022.eb.asu.ch9
