Abstract : Stomach ulcers (gastric and duodenal), gastroesophageal reflux, and Zollinger-Ellison syndrome are all examples of acid-peptic illness. Peptic ulcer disease is believed to be caused by an imbalance between the cell-destructive effects of hydrochloric acid and pepsin on the one hand and the cell-protective actions of mucus and bicarbonate on the other. Proteolytic enzyme, pepsin is activated in gastric acid that may digest the stomach wall. It causes eruption of stomach wall that leads to ulcer formation. Helicobacter pylori, a Gram-negative and spiral-shaped bacterium, is also play an important role in ulcer pathogenesis. In gastroesophageal reflux, gastric fluid enters the esophagus that cause heartburn or other symptoms like indigestion, dyspepsia, pyrosis, and so on. Zollinger-Ellison syndrome is caused by a pancreatic tumour that produces too much gastrin, which promotes stomach acid output.
Cite : Yadav, N. (2022). Drugs Used In Gastrointestinal Diseases (1st ed., p. 82). Noble Science Press. https://doi.org/10.52458/9789391842529.nsp2022.eb.asu.ch7
