Abstract : Calcium gluconate can be easily estimated when some substance is dissolved in minimum quantity of HCl and then neutralized with dil. NaOH solution and thus precipitate is formed which indicates presence of Ca2+ ion.
This titration is basically a precipitation type of titration in which a precipitate is formed after the end point. The reaction is very simple as the substance is dissolved in HCl and neutralized with dil. NaOH. As calcium is insoluble in NaOH it forms a precipitate and it indicates presence of calcium in calcium gluconate.
Cite : Kalra, M., & Tewatia, S. (2022). To Perform Assay Of Calcium Gluconate Tablet (Acid-Base Titration) And Standardization Of Titrant (1st ed., p. 68). Noble Science Press. https://doi.org/10.52458/9789391842611.nsp2022.eb.asu.ch12