Abstract : Aspirin is a weak acid that also goes through a slow process called hydrolysis. This means that each molecule of aspirin reacts with two ions of hydroxide. To get around this, a known amount of extra base is added to the sample solution, and an HCl titration is done to find out how much base hasn't reacted. This is subtracted from the initial amount of base to find the amount of base that actually reacted with the aspirin and, therefore, the amount of aspirin in the analyte. ASA is easy to dissolve in ethanol. Then, a solution of NaOH was added, and the solution was left to sit for 30 minutes with the lid on. The extra amount of NaOH is titrated with HCl solution using pH as a guide. The same titration was done again, but this time ASA was left out of the solution to act as a blank.
Cite : Kumar, K., & Diwan, A. (2022). To Perform Assay Of Aspirin (Acid-Base Titration) And Standardization Of Titrant (1st ed., p. 38). Noble Science Press. https://doi.org/10.52458/9789391842512.nsp2022.eb.asu.ch-07
